RRN, in collaboration with several like-minded civil society networks and alliances, is actively involved in policy research, advocacy, lobbying and campaigning on various issues at national, regional and global levels. RRN is mainly focused on the issues of human rights, women's rights, rights of the child, human trafficking, right to food/food sovereignty, climate justice, tax justice and right to development at national level in association with respective national networks - Human Rights Treaties Monitoring Coordination Committee (HRTMCC), National Network on Right to Food, Nepal (RtFN), Alliance Against Trafficking in Women and Children  in Nepal (AATWIN), National Coalition for Children as Zones of Peace and Child Protection (CZOPP) and Campaign for Climate Justice, Nepal (CCJN). 

Similarly, it is intensively engaged in advocacy, lobbying and campaign activities on the issues such as, rights of the Least Development Countries (LDCs), Sustainable Development Goals (SDGs), development effectiveness, cancellation of illegitimate debt, fair trade, social protection, women's rights, demilitarisation, democratisation and social justice in partnership with South Asia Alliance for Poverty Eradication (SAAPE), Asian Peoples' Movement on Debt and Development (APMDD), LDC Watch, Social Watch, CSO Partnership for Development Effectiveness (CPDE) at regional and global levels. 

RRN also hosts the national secretariat of CCJN, the regional secretariat of People's SAARC, the regional secretariat of SAAPE, and international secretariat of LDC Watch.